Am J Clin Nutr 1975;28:377-84. You should consult your physician or healthcare professional regarding your health and should not take any action with respect to content provided on this site. Eur J Nutr. View abstract. View abstract. 2020;19(1):101. View abstract. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. She felt it couldn't be causing her any harm since she couldn't even taste any bitter or metallic taste when she let the tablets dissolve in her mouth. J Pediatr.Gastroenterol.Nutr 1988;7(6):877-881. While breast-feeding, the RDA is 17 mg in those 18 years of age and 12 mg in those 19 years and older. View abstract. Flynn A, Pories WJ, Strain WH, et al. Wound Repair Regen. Am J Clin Nutr 1981;34:1479-83. Clin Exp Dermatol 1997;22:169-73. View abstract. JPed 1938;18:60-2. However, there are also side effects to consider. View abstract. Stabile, A., Pesaresi, M. A., Stabile, A. M., Pastore, M., Sopo, S. M., Ricci, R., Celestini, E., and Segni, G. Immunodeficiency and plasma zinc levels in children with Down's syndrome: a long-term follow-up of oral zinc supplementation. Dreno B, Trossaert M, Boiteau HL, Litoux P. Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Nowak, G., Siwek, M., Dudek, D., Zieba, A., and Pilc, A. BMC Oral Health 2021;21(1):364. Turner RB. View abstract. Indian J Pediatr. Palomo F, Wantland L, Sanchez A, Volpe AR, McCool J, DeVizio W. The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. Clin Rheumatol 1998;17:378-82. Here are a few types you might find on the market: Because its one of the most widely available and cost-effective forms, zinc gluconate can be a good option to bump up your intake without breaking your bank. Am.J.Trop.Med.Hyg. 2021. View abstract. 2021;35(8):4377-4387. Long, K. Z., Rosado, J. L., Montoya, Y., de Lourdes, Solano M., Hertzmark, E., DuPont, H. L., and Santos, J. I. Arch Dis Child 1997;77:196-200. View abstract. Zinc supplementation for improving pregnancy and infant outcome. Rasker JJ, Kardaun SH. WebMD does not provide medical advice, diagnosis or treatment. ferrous sulfate, folic acid, ergocalciferol, acetylcysteine, ascorbic acid, Vitamin C, biotin, multivitamin, thiamine, niacin. If you are not much into meats or seafood, other good sources include beans, whole grains, dairy products, cereals and nuts. Biol Trace Elem Res 1998;61:19-31. Ann.Trop.Paediatr. While pregnant, the RDA is 13 mg in those 18 years of age and 11 mg in those 19 years and older. View abstract. 2015 Jan;122(1):162-9. For example, a 3-ounce (85-gram) serving of beef patty contains 5.3 mg of zinc while certain types of breakfast cereal contain around 2.8 mg per serving (34). 1995 update. Sur, D., Gupta, D. N., Mondal, S. K., Ghosh, S., Manna, B., Rajendran, K., and Bhattacharya, S. K. Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in kolkata, India: a randomized, double-blind, placebo-controlled, community-based study. According to a review of 28 studies, some evidence suggests that taking zinc could even prevent symptoms and shorten the duration of certain respiratory tract infections (10). 10-1-2006;43(2):197-201. (Copenh) 1984;62(5):739-745. View abstract. 2007;25(1):67-74. N Engl J Med. Khedun SM, Naicker T, Maharaj B. Zinc, hydrochlorothiazide and sexual dysfunction. Zinc is a very important mineral but you only need to take just enough. View abstract. View abstract. J Evid Based Med 2021;14(3):185-187. View abstract. View abstract. Effect of oral contraceptive agents on nutrients: I. Bahl, R., Bhandari, N., Saksena, M., Strand, T., Kumar, G. T., Bhan, M. K., and Sommerfelt, H. Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. J Diabetes Complications. View abstract. 2012 Apr;51(4):459-62. View abstract. Pierard-Franchimont C, Goffin V, Visser JN, et al. View abstract. A type of zinc called zinc sulfate has been proven especially useful for decreasing symptoms of mild to moderate acne (16). J Nutr 2001;4:1135-41.. View abstract. Joo YS, Kim HW, Lee S, et al. Gutierrez, Castrellon P., Polanco, Allue, I, and Salazar, Lindo E. [An evidence based Iberic-Latin American guideline for acute gastroenteritis management in infants and prescholars]. Different zinc supplements contain varying concentrations of elemental zinc. Relevance of zinc in human sperm flagella and its relation to motility. Am J Clin Nutr 2002;76(6):1401-1408. But it isn't clear if this is a big concern. J Clin Periodontol. Nutr Rev. View abstract. 4. View abstract. Cochrane Database Syst Rev. Br.J.Dermatol. 2013 Dec 15;74(12):872-8. In children, the RDA depends on age. O'Connor DT, Strause L, Saltman P, et al. Warts. National Institutes of Health "Dietary supplement fact sheet: zinc. Lancet 11-26-2005;366(9500):1862-1867. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents: Drug Interactions between Integrase Inhibitors and Other Drugs. Bhandari N, Bahl R, Taneja S, et al. View abstract. Eur.J Clin Nutr 1997;51(1):33-37. Nielsen FH, Milne DB. J Pediatr.Gastroenterol.Nutr 2004;38(1):34-40. Trop.Med.Int Health 2011;16(12):1474-1482. View abstract. View abstract. Zinc is well known for its role in blood sugar management and insulin secretion. View abstract. View abstract. Effects of oral ethinyl oestradiol and norethisterone on plasma copper and zinc complexes in post-menopausal women. View abstract. View abstract. Here are five recommendations to consider: Susan noticed she was beginning to wobble when she walked.if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[300,600],'healthifybody_com-leader-1','ezslot_2',123,'0','0'])};__ez_fad_position('div-gpt-ad-healthifybody_com-leader-1-0'); For some strange reason, she was not able to put one foot in front of another. J Nutr 1995;125:66-72. J Affect Disord 1999;56:189-94. Am J Clin Nutr 2001;73:1045-51. The Problem May Be the Supplement You Don't Take, When Using Mineral Supplements, More Is Not Always Better, You will find highly beneficial ingredients in. When choosing a zinc supplement, youll likely notice that there are many different types available. J Natl Cancer Inst 2007;99:754-64. Heyman, H., Van De Looverbosch, D. E., Meijer, E. P., and Schols, J. M. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. Elfarargy MS, Al-Ashmawy G, Abu-Risha S, Khattab H. Zinc supplementation in preterm neonates with late-onset sepsis: is it beneficial? Zinc is an essential trace element commonly found in red meat, poultry, and fish. Macular degeneration is a common eye disease and one of the leading causes of vision loss around the globe (22). The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin. Prema K, Ramalakshmi Ba, Babu S. Serum copper and zinc in hormonal contraceptive users. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Eur J Neurosci 2002;15:1907-17. View abstract. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Zinc is an essential mineral that is needed by your body to manufacture about 300 enzymes. 1991;80(2):91-94. Atik OS. Intensive Care Med 2000;26:s413-21. OTHER NAME(S): Actate de Zinc, Acexamate de Zinc, Aspartate de Z. Zinc is an essential trace element commonly found in red meat, poultry, and fish. View abstract. Amiloride can increase the amount of zinc in the body. J Nutr 2000;130:1378s-83s. A randomized double-blind placebo-controlled clinical trial. Effect of oral folic acid supplements on zinc, copper, and iron absorption and excretion. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Age-Related Macular Degeneration PPP - Updated 2015. www.aao.org/preferred-practice-pattern/age-related-macular-degeneration-ppp-2015. Clin.Exp.Dermatol. Zoli A, Altomonte L, Caricchio R, et al. View abstract. But taking zinc by mouth during pregnancy might increase the growth of the child during the first year of life. View abstract. Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. View abstract. A double-blind clinical trial. J Assist Reprod Genet. Supplementing with 1530 mg of elemental zinc daily may improve immunity, blood sugar levels, and eye, heart, and skin health. Weismann K. Chelating drugs and zinc. Garcia-Plaza A, Arenas JI, Belda O, Diago A, et al. Int.J.Immunopharmacol. View abstract. Selenium, zinc, and copper changes with valproic acid: possible relation to drug side effects. Effect on weight management Monk fruit sweetener has been claimed to aid weight loss.. View abstract. Campbell IA, Elmes PC. Phase I trials of dexrazoxane and other potential applications for the agent. Gregorio, G. V., Dans, L. F., Cordero, C. P., and Panelo, C. A. Zinc supplementation reduced cost and duration of acute diarrhea in children. Castilla-Higuero, L., Romero-Gomez, M., Suarez, E., and Castro, M. Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease. Henkin RI, Martin BM, Agarwal RP. Asparatame causes such side effects as anxiety, depression, short-term memory loss, fibromyalgia, weight gain, fatigue, brain tumors and more. American Regent Laboratories Inc (2012): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Anon. Clin Immunol.Immunopathol. Biol Trace Elem Res. Urol Res 1984;12:213-5. Zinc and copper nutriture of women taking oral contraceptive agents. Saudi.Med.J 2007;28(9):1418-1421. Crown LA, May JA. Invest Ophthalmol Vis Sci 1996;37:1225-35. View abstract. 3. Eur J Pediatr 1985;143:310-4. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. Dubourg G, Lagier JC, Brouqui P, et al. Giving zinc by mouth to infants or children at risk for having low levels of zinc doesn't seem to improve development. 2013;30(4):593-9. Washington, DC: National Academy Press, 1999. View abstract. Klin.Wochenschr. Eur.J Clin Nutr 2009;63(1):65-70. Increasing Obesity Risk. Faruque AS, Mahalanabis D, Haque SS, et al. View abstract. 2012 Dec 12;12:CD007991. Available for Android and iOS devices. View abstract. A. They were especially severe, and they did not cause a lot of inflammation, but after three months they did not go away. Biol Psychiatry. Pediatrics 2007;119:1120-30. Walker, C. L. and Black, R. E. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. View abstract. Zinc may also act as an antioxidant, reducing inflammation and protecting against chronic conditions like heart disease, cancer, and diabetes (8, 9). Zinc can decrease the amount of tetracyclines the body absorbs. Henkel R, Bittner J, Weber R, et al. Use of topical zinc to prevent recurrent herpes simplex infection: review of literature and suggested protocols. J Pediatr 1999;135:689-97. View abstract. Donangelo CM, Woodhouse LR, King SM, et al. It may also damage the bacterial environment in your gut, but this needs to be studied in humans. Hyun TH, Barrett-Connor E, Milne DB. 1996;20(5):457-462. Options: View abstract. Kingberg WG, Prasad AS, Oberleas D. Zinc deficiency following penicillamine therapy. Cent Afr J Med 1995;41:312-5. View abstract. Now, the obvious explanation for this finding would be reverse causation. View abstract. Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Charoenngam N, Ponvilawan B, Ungprasert P. Higher zinc intake is associated with decreased risk of lung cancer. Hinojosa, J., Prosper, M., Primo, J., and Moles, J. R. [The effect of a single nighttime dose of zinc acexamate (ZAC) on basal and pentagastrin-stimulated gastric secretion]. View abstract. Abdulhamid, I., Beck, F. W., Millard, S., Chen, X., and Prasad, A. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. Dhingra U, Kisenge R, Sudfeld CR, et al. Acta Derm.Venereol. Stevia can cause gastrointestinal side effects in some. Nutr Res 2000;20:1079-89. According to a 2012 study, a glycoside called stevioside found in stevia plants helps boost cancer cell death in a human breast cancer line. J Am Coll Nutr 2001;20:106-18. View abstract. Br J Dermatol 1977;97:561-6. Thus, more research is needed (21). J Neurotrauma 1996;13:25-34. Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: a randomized controlled trial. Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Efficacy of a dentifrice containing zinc citrate for the control of plaque and gingivitis: a 6-month clinical study in adults. Other reviews similarly recommend zinc supplements to slow the progression of AMD, claiming that it may improve nutrient flow in the retina to protect against disease (24, 25). An olfactometric and anatomical study. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized, controlled trial. View abstract. Eur J Clin Pharmacol 1975;9:131-4. A zinc dose of 40 milligrams is approved safe to use by FDA and a zinc dosage more than this can pose certain risks. All-Purpose In The Raw Nature's Zero Calorie Sweetener, Sugar Free Substitute Baking, Coffee, Stevia, Monk Fruit, Allulose, Erythritol Blend, Keto, Low Carb, Vegan, Gluten Free, 14 Oz (Pack of 1) 1,562. Desferrioxamine and urinary zinc excretion in beta-thalassemia major. In: Prasad AS (ed). II. Rapid serum zinc depletion associated with corticosteroid therapy. Camacho FM, Garcia-Hernandez MJ. Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet. A., Lassi, Z. S., Ahmed, A., and Bhutta, Z. View abstract. Metabolism 1990;39:665-7. Lazzerini, M. and Ronfani, L. Oral zinc for treating diarrhoea in children. View abstract. 2020;28(12):1-12. Bhutta, Z. View abstract. J Clin Pathol 1983;36:1016-21. View abstract. Oshvandi K, Vafaei SY, Kamallan SR, Khazaei S, Ranjbar H, Mohammadi F. Effectiveness of zinc chloride mouthwashes on oral mucositis and weight of patients with cancer undergoing chemotherapy. Fjellner, B. Drug-induced lupus erythematosus aggravated by oral zinc therapy. Curr Ther Res 1998;59:595-607. Meanwhile, if youre able to invest a bit more, zinc picolinate may be better absorbed. Arch.Intern.Med 11-10-1997;157(20):2373-2376. 2012;6:CD005436. View abstract. Respir Care. Quackwatch 2000. View abstract. Clin Lab Med 1998;18:673-85. Mazaheri Nia L, Iravani M, Abedi P, Cheraghian B. View abstract. Polat, T. B., Uysalol, M., and Cetinkaya, F. Efficacy of zinc supplementation on the severity and duration of diarrhea in malnourished Turkish children. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. J Antimicrob Chemother 1987;20:893-901. Rittenhouse T. The management of lower-extremity ulcers with zinc-saline wet dressings versus normal saline wet dressings. Dronfield MW, Malone JD, Langman MJ. And to ensure that your zinc supplements never cause overdose symptoms, make sure you get 3 milligrams (just 3!) 2012 Apr;129(4):701-8. 2020;20(1):212. View abstract. Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhea. Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. View abstract. View abstract. Cadmium in zinc-containing mineral supplements. 2012;4(7):648-675. A double-blind clinical trial. Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects. Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects. Loss of sense of smell with intranasal cold remedies containing zinc. View abstract. View abstract. Women may experience additional side. View abstract. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Zinc metabolism during captopril treatment. View abstract. Am J Clin Nutr 2000;72:1516-22. Am J Clin Nutr 1985;41(2):285-292. Am J Clin Nutr 1998;68:442S-6S. View abstract. One review reported that low zinc levels could be linked to impaired blood sugar levels and type 2 diabetes (12). Many people turn to zinc lozenges and supplements when they feel sick, and for good reason. Consider consulting with a healthcare professional if symptoms persist. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. View abstract. Schisterman EF, Sjaarda LA, Clemons T, et al. Dr. Ranjit Chandra, who was a pediatrician and immunologist at the Memorial University of Newfoundland, and who more recently formulated vitamin and mineral products for the Javaan Corporation in the United States, first addressed the problem of zinc overdoses when taking large amounts of zinc was popular, in the 1980's, pointed out that zinc deficiency was (and is) a common nutritional problem in North America, especially among older adults. Nutrients. Large-scale population studies have found that the consumption of artificial sweeteners, particularly in diet sodas, is associated with increased weight gain and abdominal fat over time. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. Wittes J, Musch DC. Indian J Physiol Pharmacol. View abstract. View abstract. 2007;47(3):216-221. 2013 Oct;98(4):960-71. Rossander-Hulten L, Brune M, Sandstrom B, et al. Nutrients 2022;14(5):1055. Yousefichaijan P, Naziri M, Taherahmadi H, Kahbazi M, Tabaei A. Zinc supplementation in treatment of children with urinary tract infection. Lin, Y. S., Lin, L. C., and Lin, S. W. Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis. J Am Coll Nutr 1995;14:364-8. Walker, C. L., Bhutta, Z. View abstract. Eur J Dermatol 2000 May;10:269-73. 2016;124(1):28-33. View abstract. 2021;16(1):e0244823. Hasinoff BB. Artificial sweeteners may also have an effect on some people's immune systems. Competitive inhibition of iron absorption by manganese and zinc in humans. Bogden, J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., and Holland, B. K. Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. Faghfouri AH, Khabbazi A, Baradaran B, et al. BMC Pregnancy Childbirth. A., Sowa-Kucma, M., Zieba, A., Popik, P., Pilc, A., and Nowak, G. Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. View abstract. 7. A., Musharrafieh, U. M., Tamim, H., and Hamadeh, G. N. Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. Br.J Nutr 2006;95(5):963-967. Especially at risk are older adults who eat little or no meat but lots of whole grains and fiber. Farhang B, Grondin L. The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study. Cochrane Database Syst Rev. Ear infection (otitis media). J Pediatr 1998;132:467-71. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90.. View abstract. Dermatology 2004;209(1):46-49. Freeland-Graves JH, Lin PH. Nutrition 2021;91-92:111418. View abstract. Taking zinc by mouth doesn't seem to help with hair loss. Int J Food Sci Nutr 2001;52:379-82.. View abstract. The symptoms go away soon after discontinuation. Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trial. Med J Aust. Schiliro G, Russo A, Azzia N, et al. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects. While several studies have identified potential side effects of stevia over the last few decades, most were done using laboratory animals, and many have since been disproved. View abstract. Nutr Neurosci. Int Dent J 1993;43:431-9. Head to the diet generator and enter the number of calories you want. Einstein (Sao Paulo). B. Zinc and vitamin A supplementation in Australian Indigenous children with acute diarrhoea: a randomised controlled trial. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. Collipp, P. J. Ann.Rheum.Dis. 2010;21(3):237-246. Effectiveness of oral zinc sulfate therapy in lesion regression. View abstract. Zinc-induced copper deficiency in an infant. When used as directed, zinc supplements can be a safe and effective way to increase your zinc intake and improve several aspects of your health. View abstract. Acesulfame potassium is an artificial sweetener. View abstract. Jackson, J. L., Peterson, C., and Lesho, E. A meta-analysis of zinc salts lozenges and the common cold. Crofton RW, Gvozdanovic D, Gvozdanovic S, et al. The effect of zinc supplementation on parasitic reinfestation of Guatemalan schoolchildren. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Strand, T. A., Chandyo, R. K., Bahl, R., Sharma, P. R., Adhikari, R. K., Bhandari, N., Ulvik, R. J., Molbak, K., Bhan, M. K., and Sommerfelt, H. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. You should consult your physician or healthcare professional regarding your health and should not take any action with respect to content provided on this site. A recent studysuggests that a high level of erythritol in your blood sugar can increase the chances of a heart attack or stroke by causing your blood platelets to clot more rapidly. J Health Popul.Nutr. FDA Office of Nonprescription Products. Zinc and immunity. Symptoms of a zinc deficiency include decreased immunity, hair loss, poor appetite, diarrhea, and slow wound healing (1). View abstract. View abstract. BMC Pediatr 2020;20(1):451. Folic acid: effect on zinc absorption in humans and in the rat. Hillstrom L, Pettersson L, Hellbe L, et al. Age-Related Eye Disease Study Research Group. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Once possessing a radiant complexion, she grew more and more pale. 2005;9(12):1378-1384. As such, more research is needed to learn more about the connection between this mineral and eye health. Am J Clin Nutr. King JC. View abstract. View abstract. J Am Coll Nutr 1983;2:157-62. Lagiou P, Wuu J, Trichopoulou A, et al. Mocchegiani E, Veccia S, Ancarani F, et al. Taking zinc with penicillamine might decrease the effects of penicillamine. One review of 7 studies showed that zinc lozenges containing 8092 mg of zinc may reduce the duration of the common cold by up to 33% (7). Total zinc absorption in young women, but not fractional zinc absorption, differs between vegetarian and meat-based diets with equal phytic acid content. Zinc supplement use and risk of prostate cancer. Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea. View abstract. View abstract. Eur J Nutr 2021. Botash AS, Nasca J, Dubowy R, et al. 1996;53(10):1017-1025. With a healthcare professional if symptoms persist obvious explanation for this finding would reverse. 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