This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Unless youre, say, an expat living in China, you can definitely find a better option. Thank you for the positive feedback. . Fleas were treated with effifax, active ingredient fipronil. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Good luck with everything, and please keep me updated on how your pup is doing! Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. It provides 100% protection from heartworm disease. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. However, as with any chemical compounds, caution is advised even with products deemed to be safe. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co Im glad you found this information helpful. ? Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . Is Frontline Plus still safe? new post updates in monthly email newsletters. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Have you had any issues with Seresto? To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. Simparica trio prescribed to 10 wk aussie pup. This organic powder is great for a variety of uses. That way if a tick does make it past the essential oil barrier and bite, itll die anyway. -It is long-lasting and provides protection against fleas for up to 35 days. Product Description. Is this vaccine something youve heard of? And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) I know youre very particular about the genetic health of your Collies, and I admire your breeding program. For my Aussie mix, Ive had success using Advantix II. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Tap to zoom. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. Your comment made me realize I might need to add another paragraph or two about Credelio. Happy to help! A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Thank you. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Nothing could be done for them. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. The drawback of Advantage is that it does not offer any protection against ticks. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) Thanks for your efforts to help! Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. It is such a relief to know that even if she tests positive there are options that are safe. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. . 3,4,7-9 Most notably, a series of randomized . Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Its worth making a phone call to see what they would recommend for your pup. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Im happy to hear it and so glad it helped! Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. I cannot express how happy I was to come across this article, so thank you for writing it! One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Happy to be of help! However, it does claim to kill fleas on contact. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. In FL resistance is bad, and we split our time between FL & NJ. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. . I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. You might want to look at the information on Nexgard. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Do you know what the ingredients are in the medicated shampoo? Much appreciated! Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Hope this helps! Sugar is almost 4 months old now! Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. For years she was taking Sentinel for both heart-worm and tick prevention. However, not all MLs are created equal, and some are safer than others. collies. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. Rev. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Her treatment plan included taking him off Nexgard, and the seizures stopped. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. tratados. The author states this had no connection to the drug study. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Evoluciona. As with any topical, of course keep an eye out for skin irritation. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Dash is MDR1 mutant/normal. Unfortunately, the fleas are fighting back. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Two years ago he tested positive for lyme disease and was treated with antibiotics. Waxman and Brooks both recommend it. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. It covers fleas, ticks, and heart worms. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). My vet wants to give him a vaccine (?) Select in Checkout If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Their treatment for this was nexgard and medicated baths. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. This product is an awesome all in one, monthly chewable tablet. Simparica Trio 11.1-22 lbs. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Product Description. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. Our dogs deserve the best. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Now: $92.79. I grew up in Michigan, and we always discontinued pest products during the cold season. SIMPARICA TRIO tested positive for heartworm disease. Wow! My pleasure! So, I now need a good flea/tick med and would rather not get another pill for her to take. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. This year she has a very high degree of irritation when applied (I had to wash it off). (Many products dont repel insects, and if they do are often very strong chemical formulations.). I just quote the ones who are knowledgeable about MDR1. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). I think this is a couple years old. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Happy to help! Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Later, the vet had the experience of this happening to other cats and one of his own. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Giardia can be passed to and cause diarrhea in humans. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Dogs, 6 Month Supply. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. I am so excited. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. . Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. She had a severe reaction with diarrhea, drooling, depression etc. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. Please keep me updated if you think of it! Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). Thank you for such a great article! MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. Appreciated!!! However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. By Dkamplain to improve your grades up in Michigan just outside Detroit so his walks consist of concrete and! Thank you for writing it to meet someone, in person or virtually with. This excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton it... 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